Quantitative framework of Redundant and Unique Metabolic Capabilities of Various Organisms Residing in Human Microbiomes
Microbiology- Grade:
- 10
- Teacher:
- Mari Echols
Human microbiomes contain diverse microbial communities that perform essential metabolic functions for host health. It remains unclear which of these functions are shared across body sites and which are specialized for particular environments. This study develops a quantitative framework to compare the redundant and unique metabolic capabilities of microorganisms in the human gut, skin, and oral microbiomes using publicly available MGnify genomes and KEGG functional annotations. Representative bacterial species from each microbiome were functionally profiled and analyzed using principal component analysis (PCA) to identify similarities in metabolic potential for all bacterial species, followed by Venn comparisons to determine shared and niche-specific pathways through KEGG modules.
Your statistical analysis and prowess is amazing to see! Your data is meaningful and well-done! The intersection of statistics, bioinformatics, microbiology, and health makes your project even more impactful. Continue on this path, and you will have a wonderful career in statistical analysis, biology, or the wider sciences!