Effect of Temperature Conditions on NRF2 Protein Crystal Formation
Cellular and Molecular Biology and Biochemistry
Sameer Sandhu
- Grade:
- 12
- Teacher:
- David Stropka
This project attempted to find the ideal temperature conditions to grow crystals of the NRF2 protein, which would eventually be used for X-ray crystallography. Low temperature (4C) and room temperature (25C) were tested. Once the X-ray crystallography is complete, the solved structure of NRF2 will lead to improved NRF2-targeted drugs, creating a potential for improved cancer and diabetes treatments as NRF2 plays roles in these diseases.