Effect of Temperature Conditions on NRF2 Protein Crystal Formation

Cellular and Molecular Biology and Biochemistry
Sameer Sandhu

David Stropka

This project attempted to find the ideal temperature conditions to grow crystals of the NRF2 protein, which would eventually be used for X-ray crystallography. Low temperature (4C) and room temperature (25C) were tested. Once the X-ray crystallography is complete, the solved structure of NRF2 will lead to improved NRF2-targeted drugs, creating a potential for improved cancer and diabetes treatments as NRF2 plays roles in these diseases.

Project presentation

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Lab journal excerpts

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Research paper

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